| 1886 |
 Founder Chubei Kobayashi established Kobayashi Seidaido, an unlimited partnership company, in Monzen-cho, Naka-ku, Nagoya
The Company sold general merchandise, cosmetics |
| 1894 |
 Launched 10 types of proprietary pharmaceuticals including Daikokumaru, Ichinichimaru and Tamushichinki |
| 1912 |
Established Kobayashi Daiyakubou, a limited partnership company, in Hiranomachi, Higashi-ku, Osaka |
| 1919 |
Incorporated as Kobayashi Daiyakubou Co., Ltd. in Kyomachibori, Nishi-ku, Osaka through a merger involving unlimited partnership company Kobayashi Seidaido and limited partnership company Kobayashi Daiyakubou |
| Kichitaro Kobayashi is appointed as the first president |
| 1939 |
Launched Hakkiri, a headache medicine |
| 1940 |
Spun off the manufacturing unit of Kobayashi Daiyakubo, to establish Kobayashi Pharmaceutical Co., Ltd. |
| Juso Plant began operations in Higashi-yodogawa-ku, Osaka (currently Yodogawa-ku) |
| 1948 |
Saburo Kobayashi is appointed as the second president |
| 1956 |
Kobayashi Daiyakubou Co., Ltd. and Kobayashi Pharmaceutical Co., Ltd. were merged and renamed Kobayashi Pharmaceutical Co., Ltd. |
| Relocated the Head Office to Dosho-machi, Higashi-ku, Osaka (currently Dosho-machi, Chuo-ku) |
| 1958 |
Teruko Kobayashi is appointed as the third president |
| 1967 |
 Launched Ammeltz, an external anti-inflammatory |
| 1969 |
 Launched Bluelet, a toilet bowl cleaner, and entered the houshold products market |
| 1972 |
Formed partnership with C.R. Bard, Inc.,of the U.S. to establish medical devices importer-Japan Medico, Inc. and enter the medical devices market |
| 1975 |
 Launched Sawaday, a toilet air freshener, and entered the deodorizing air fresheners market |
| 1976 |
Kazumasa Kobayashi is appointed as the fourth president |
| Japan Medico, Inc. became Medicon, Inc., a joint venture company with C.R. Bard, Inc. |
| 1983 |
Established Toyama Kobayashi Pharmaceutical Co., Ltd. (Toyama City, Toyama Prefecture) |
| 1988 |
Angel Ltd. made a consolidated subsidiary of Kobayashi Pharmaceutical Co., Ltd to gain a manufacturing site (Niihama City, Ehime Prefecture) |
| 1992 |
Established Kobayashi Medical, as part of the Medical Devices Business |
| 1993 |
Established Sendai Kobayashi Pharamaceutical Co., Ltd. (Kurokawa-gun, Miyagi Prefecture) |
| 1996 |
Launched Toughdent, denture cleanser |
| 1998 |
Established Shanghai Kobaysahi Friendship Daily Chemicals Co., Ltd., a joint venture company in China |
| Established Kobayashi Healthcare, Inc. in the U.S. |
| 1999 |
Listed on the Second Section of the Osaka Securities Exchange |
| Launched nutritional supplements through the mail order sales channel |
| 2000 |
Listed on the First Section of the Tokyo Stock Exchange and Osaka Securities Exchange |
| Established the Central R&D Laboratory in Ibaraki City, Osaka Prefecture |
| Spun-off the Trade Company to form Kobashou Co., Ltd. |
| 2001 |
Acquired Kiribai Chemical Co., Ltd. a body warmer manufacturer, as a subsidiary (Yodogawa-ku, Osaka) |
| Established Kobayashi Healthcare Europe, Ltd. in the United Kingdom |
| 2002 |
Established Kobayashi Pharmaceutical (Hong Kong) Co., Ltd. in Hong Kong |
| Made Shanghai Kobayashi Friendship Daily Chemicals Co., Ltd. into a wholly owned subsidiary and changed its name to Shanghai Kobayashi Daily Chemicals Co., Ltd. |
| Took over the health food business, mainly for Tochucha (Eucommia leaf tea), from Hitachi Zosen Corporation |
| 2003 |
Angel Ltd. renamed Ehime Kobayashi Pharmaceutical Co., Ltd. |
| 2004 |
Yutaka Kobayashi is appointed as the fifth president |
| 2005 |
Obtained exclusive distribution rights for women's health medicine Inochi No Haha A from Sasaokayakuhin Corporation |
| 2006 |
Made eVent Medical Ltd., a medical device manufacturer, into a subsidiary in Ireland |
| Made HeatMax Inc., a body warmer manufacturer in the U.S., into a subsidiary |
| 2008 |
Kobasho Co., Ltd. and Mediceo Paltac Holdings Co., Ltd. conducted share exchage |
| Spun off the manufacturing division of Kiribai Chemical Co., Ltd. to establish Kiribai Kobayashi Pharmaceutical Co., Ltd. |
| Obtained trademark right for Bisrat Gold from Ishihara Chemical Co., Ltd. |
| 2009 |
Established Kobayshi Pharmaceutical (Singapore) Pte. Ltd. in Singapore |
| 2010 |
Spun off medical device division into Kobayashi Medical Co., Ltd. |
| 2011 |
Transferred all eVent Medical INC. shares in a management buy-out |
| Established Kobayashi Healthcare (Malaysia) Sdn. Bhd. in Malaysia |
| Established Kobayashi Pharmaceutical(Taiwan) Co., Ltd. in Taiwan |
| 2012 |
Made Grabber, Inc., a body warmer manufacturer in the U.S., a subsidiary |
| Established PT. Kobayashi Pharmaceutical Indonesia in Indonesia |
| Transferred 80% of Kobayashi Medical Co., Ltd. shares to Mitsubishi Corporation |
